Article
Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.
PLoS pathogens - 1 Jan 2013
Mbonye Uri R, Gokulrangan Giridharan, Datt Manish, Dobrowolski Curtis, Cooper Maxwell, Chance Mark R, Karn Jonathan
Abstract excerpt
The HIV transactivator protein, Tat, enhances HIV transcription by recruiting P-TEFb from the inactive 7SK snRNP complex and directing it to proviral elongation complexes. To test the hypothesis that T-cell receptor (TCR) signaling induces critical post-translational modifications leading to enhanced interactions between P-TEFb and Tat, we employed affinity purification-tandem mass spectrometry to analyze P-TEFb....
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