Article
Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA.
Molecular and cellular biology - 1 Dec 2012
D'Orso Iván, Jang Gwendolyn M, Pastuszak Alexander W, Faust Tyler B, Quezada Elizabeth, Booth David S, Frankel Alan D
Abstract excerpt
Transcription factors regulate eukaryotic RNA polymerase II (Pol II) activity by assembling and remodeling complexes at multiple steps in the transcription cycle. In HIV, we previously proposed a two-step model where the viral Tat protein first preassembles at the promoter with an inactive P-TEFb:7SK snRNP complex and later transfers P-TEFb to TAR on the nascent transcript, displacing the inhibitory snRNP and...
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