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Article

CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.

Retrovirology - 9 Nov 2012

Breuer Denitra, Kotelkin Alexander, Ammosova Tatiana, Kumari Namita, Ivanov Andrey, Ilatovskiy Andrey V, Beullens Monique, Roane Philip R, Bollen Mathieu, Petukhov Michael G, Kashanchi Fatah, Nekhai Sergei

Abstract excerpt

BACKGROUND: HIV-1 transcription is activated by the viral Tat protein that recruits host positive transcription elongation factor-b (P-TEFb) containing CDK9/cyclin T1 to the HIV-1 promoter. P-TEFb in the cells exists as a lower molecular weight CDK9/cyclin T1 dimer and a high molecular weight complex of 7SK RNA, CDK9/cyclin T1, HEXIM1 dimer and several additional proteins. Our previous studies implicated CDK2 in...

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Source

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Identifiers

PMID: 23140174
DOI: 10.1186/1742-4690-9-94
PMCID: PMC3515335

Genes

CDK9
CDK2
HEXIM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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