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Article

Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.

PloS one - 21 Apr 2011

Ammosova Tatiana, Obukhov Yuri, Kotelkin Alexander, Breuer Denitra, Beullens Monique, Gordeuk Victor R, Bollen Mathieu, Nekhai Sergei

Abstract excerpt

The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII). CDK9 activity is regulated by protein phosphatase-1 (PP1) which was previously shown to dephosphorylate CDK9 Thr186. Here, we analyzed the effect of PP1 on RNAPII phosphorylation and CDK9 activity. The selective inhibition of PP1 by okadaic acid and by NIPP1...

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Share to Electrophoresis, Polyacrylamide Gel
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21533037
DOI: 10.1371/journal.pone.0018985
PMCID: PMC3080879

Genes

CDK9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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