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Article

Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.

Retrovirology - 3 Nov 2006

Ammosova Tatyana, Berro Reem, Jerebtsova Marina, Jackson Angela, Charles Sharroya, Klase Zachary, Southerland William, Gordeuk Victor R, Kashanchi Fatah, Nekhai Sergei

Abstract excerpt

BACKGROUND: Transcription of HIV-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of RNA polymerase II (RNAPII) C-terminal domain (CTD) by CDK9/cyclin T1. Earlier we showed that CDK2/cyclin E phosphorylates HIV-1 Tat in vitro. We also showed that CDK2 induces HIV-1 transcription in vitro and that inhibition of CDK2 expression by RNA interference inhibits HIV-1 transcription and viral...

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Share to Cyclin-Dependent Kinase 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, tat

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Share to tat Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 17083724
DOI: 10.1186/1742-4690-3-78
PMCID: PMC1636661

Genes

CDK2
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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