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Article

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.

The Journal of biological chemistry - 6 Feb 2004

Chen Ruichuan, Yang Zhiyuan, Zhou Qiang

Abstract excerpt

The positive transcription elongation factor b (P-TEFb), comprising CDK9 and cyclin T, stimulates transcription of cellular and viral genes by phosphorylating RNA polymerase II. A major portion of nuclear P-TEFb is sequestered and inactivated by the coordinated actions of the 7SK snRNA and the HEXIM1 protein, whose induced dissociation from P-TEFb is crucial for stress-induced transcription and pathogenesis of...

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Source

Identifiers

PMID: 14627702
DOI: 10.1074/jbc.M310044200

Genes

CDK9
HEXIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.PMID 14627702Read ↗

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Semantic proximity Read ↗

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.Semantic proximity Read ↗

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.Semantic proximity Read ↗

A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.Semantic proximity Read ↗

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.Semantic proximity Read ↗

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.Semantic proximity Read ↗

METTL3 promotes cell-cycle progression via activation of transcriptional elongation.Semantic proximity Read ↗

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.Semantic proximity Read ↗

Regulation of P-TEFb elongation complex activity by CDK9 acetylation.Semantic proximity Read ↗

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.Semantic proximity Read ↗

T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.Semantic proximity Read ↗

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase IISemantic proximity Read ↗

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