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Article

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+T cells

2 Oct 2006

Abstract excerpt

BACKGROUND: The latent reservoir of human immunodeficiency virus type 1 (HIV-1) in resting CD4+ T cells is a major obstacle to the clearance of infection by highly active antiretroviral therapy (HAART). Recent studies have focused on searches for adjuvant therapies to activate this reservoir under conditions of HAART. Prostratin, a non tumor-promoting phorbol ester, is a candidate for such a strategy. Prostratin...

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PMID: 17014716
DOI: 10.1186/1742-4690-3-66

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