HIV-1 latency reversing agents converge on phosphoregulation of nuclear protein complexes

Abstract excerpt

<h4>ABSTRACT</h4> Despite the success of antiretroviral therapy (ART), HIV-1 persists in latently infected cells, posing a central barrier to a cure. “Shock-and-kill” strategies using latency-reversing agents (LRAs) have shown some promise in reactivating viral gene expression ex vivo , but have yielded little clinical efficacy, underscoring the need for deeper insight into the molecular mechanisms that govern r...

Topics

Open a Topic to create a Post that cites this publication.

• Amino Acid Sequence
• Cell Line
• Cytomegalovirus and herpesvirus research
• Gene Expression Regulation, Viral
• HIV/AIDS drug development and treatment
• HIV/AIDS Research and Interventions
• HIV Research and Treatment
• Human T-lymphotropic virus 1

Identifiers and source

Literature Corpus work

1be27dc0-d898-545b-9f94-ae47e7767cbc

DOI

10.1101/2025.11.13.688376