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Article

Short- and long-term effects of LRRK2 on axon and dendrite growth.

PloS one - 1 Jan 2013

Sepulveda Bryan, Mesias Roxana, Li Xianting, Yue Zhenyu, Benson Deanna L

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) underlie an autosomal-dominant form of Parkinson's disease (PD) that is clinically indistinguishable from idiopathic PD. The function of LRRK2 is not well understood, but it has become widely accepted that LRRK2 levels or its kinase activity, which is increased by the most commonly observed mutation (G2019S), regulate neurite growth. However, growth has not been...

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Source

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Identifiers

PMID: 23646112
DOI: 10.1371/journal.pone.0061986
PMCID: PMC3640004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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