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Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5

30 Sept 2010

Abstract excerpt

Neurite outgrowth and its maintenance are essential aspects of neuronal cells for their connectivity and communication with other neurons. Recent studies showed that over-expression of either leucine-rich repeat kinase 2 (LRRK2), whose mutations are associated with familial Parkinson's disease (PD), or Rab5b, an early endosomal marker protein, induces reduction in neurite length. Based on our recent findings that...

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PMID: 22110348
DOI: 10.5607/en.2010.19.2.97

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