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Article

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 2010

Lee Seongsoo, Liu Hsin-Ping, Lin Wei-Yong, Guo Huifu, Lu Bingwei

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are linked to familial as well as sporadic forms of Parkinson's disease (PD), a neurodegenerative disease characterized by dysfunction and degeneration of dopaminergic and other types of neurons. The molecular and cellular mechanisms underlying LR...

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Source

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Identifiers

PMID: 21159966
DOI: 10.1523/JNEUROSCI.1807-10.2010
PMCID: PMC3045823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21159966-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.PMID 21159966Read ↗

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