Article
The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
Neuron - 22 Nov 2006
MacLeod David, Dowman Julia, Hammond Rachel, Leete Thomas, Inoue Keiichi, Abeliovich Asa
Abstract excerpt
Mutations in LRRK2 underlie an autosomal-dominant, inherited form of Parkinson's disease (PD) that mimics the clinical features of the common "sporadic" form of PD. The LRRK2 protein includes putative GTPase, protein kinase, WD40 repeat, and leucine-rich repeat (LRR) domains of unknown function....
Topics
- Animals
- Animals, Newborn
- Apoptosis
- Brain
- Cell Shape
- Cells, Cultured
- Genetic Predisposition to Disease
- Humans
- Inclusion Bodies
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes
- Mice