Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2020

Onishi Keisuke, Tian Runyi, Feng Bo, Liu Yiqiong, Wang Junkai, Li Yinan, Zou Yimin

Abstract excerpt

Axon-axon interactions are essential for axon guidance during nervous system wiring. However, it is unknown whether and how the growth cones communicate with each other while sensing and responding to guidance cues. We found that the Parkinson's disease gene, leucine-rich repeat kinase 2 (LRRK2), has an unexpected role in growth cone-growth cone communication. The LRRK2 protein acts as a scaffold and induces...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frizzled Receptors

Share to Gene Knockdown Techniques

Share to Growth Cones

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Neurogenesis

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 32641508
DOI: 10.1073/pnas.1921878117
PMCID: PMC7395514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.PMID 32641508Read ↗

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.Semantic proximity Read ↗

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.Semantic proximity Read ↗

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contextsSemantic proximity Read ↗

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.Semantic proximity Read ↗

The synaptic function of LRRK2.Semantic proximity Read ↗

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Semantic proximity Read ↗

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synucleinSemantic proximity Read ↗

Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.Semantic proximity Read ↗

LRRK2: an éminence grise of Wnt-mediated neurogenesis?Semantic proximity Read ↗

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4Semantic proximity Read ↗

JIP3 regulates bi-directional organelle transport in neurons through its interaction with dynein and kinesin-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.