Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.

Bioscience reports - 30 Oct 2020

Lobbestael Evy, Van den Haute Chris, Macchi Francesca, Taymans Jean-Marc, Baekelandt Veerle

Abstract excerpt

Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene belong to the most common genetic causes of inherited Parkinson's disease (PD) and variations in its locus increase the risk to develop sporadic PD. Extensive research efforts aimed at understanding how changes in the LRRK2 function result in molecular alterations that ultimately lead to PD. Cellular LRRK2-based models revealed several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Cell Culture Techniques
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Genetic Vectors

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Parkinson Disease

Share to Protein Aggregates

Source

Open in PubMed Open full text

Identifiers

PMID: 32975566
DOI: 10.1042/BSR20202225
PMCID: PMC7560525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.PMID 32975566Read ↗

The familial Parkinsonism gene LRRK2 regulates neurite process morphology.Semantic proximity Read ↗

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.Semantic proximity Read ↗

Cellular effects of LRRK2 mutations.Semantic proximity Read ↗

LRRK2 signaling pathways: the key to unlocking neurodegeneration?Semantic proximity Read ↗

Mechanisms of LRRK2-mediated neurodegeneration.Semantic proximity Read ↗

LRRK2 Parkinson disease mutations enhance its microtubule association.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Semantic proximity Read ↗

LRRK2 in Parkinson's disease: function in cells and neurodegeneration.Semantic proximity Read ↗

Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-outSemantic proximity Read ↗

Neuronal death signaling pathways triggered by mutant LRRK2.Semantic proximity Read ↗

Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase InhibitionSemantic proximity Read ↗

Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-SynucleinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.