Article
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Molecular neurodegeneration - 30 May 2012
Hinkle Kelly M, Yue Mei, Behrouz Bahareh, Dächsel Justus C, Lincoln Sarah J, Bowles Erin E, Beevers Joel E, Dugger Brittany, Winner Beate, Prots Iryna, Kent Caroline B, Nishioka Kenya, Lin Wen-Lang, Dickson Dennis W, Janus Christopher J, Farrer Matthew J, Melrose Heather L
Abstract excerpt
Mutations in the LRRK2 gene are the most common cause of genetic Parkinson's disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.We created mice lacking exon 41 that encodes the activation...
Topics
- Animals
- Autophagy
- Behavior, Animal
- Dopamine
- Kidney
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Mice, Inbred C57BL
- Mice, Knockout