Article
No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts.
PloS one - 1 Jan 2015
Garcia-Miralles Marta, Coomaraswamy Janaky, Häbig Karina, Herzig Martin C, Funk Natalja, Gillardon Frank, Maisel Martina, Jucker Mathias, Gasser Thomas, Galter Dagmar, Biskup Saskia
Abstract excerpt
Mutations within the LRRK2 gene have been identified in Parkinson's disease (PD) patients and have been implicated in the dysfunction of several cellular pathways. Here, we explore how pathogenic mutations and the inhibition of LRRK2 kinase activity affect cytoskeleton dynamics in mouse and human...
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