Article

Effect of G <sub>4</sub> C <sub>2</sub> Repeat Expansions on the Motion of Lysosomes Inside Neurites

2021-10-30

Abstract excerpt

The G 4 C 2 hexanucleotide repeat expansion in the c9orf72 locus is one among a plethora of mutations associated with amyotrophic lateral sclerosis. It accounts for the majority of disease cases. The exact processes underlying the pathology of this mutation remain elusive, yet recent evidence suggests a mechanism that disrupts axonal trafficking. Here, we used a neuronal cell line with and without the G 4 C 2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b199d06-b056-514f-9c07-9a8c9dc15da3
DOI: 10.1101/2021.10.29.466472

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effect of G <sub>4</sub> C <sub>2</sub> Repeat Expansions on the Motion of Lysosomes Inside NeuritesDOI 10.1101/2021.10.29.466472Read

<i>C9orf72</i> -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motilitySemantic proximity Read

<i>C9orf72</i> -derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neuronsSemantic proximity Read

The molecular mechanism of uptake and cell-to-cell transmission of arginine-containing dipeptide repeat proteinsSemantic proximity Read

Single-particle fluorescence tracking combined with TrackMate assay reveals highly heterogeneous and discontinuous lysosomal transport in freely orientated axonsSemantic proximity Read

Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networksSemantic proximity Read

Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTDSemantic proximity Read

Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD.Semantic proximity Read

Neuronal messenger ribonucleoprotein transport follows an aging Lévy walkSemantic proximity Read

Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by photoinducible platformSemantic proximity Read

Short- and long-term effects of LRRK2 on axon and dendrite growth.Semantic proximity Read

The sets of kinesins and dynein transporting endocytic cargoes determine the effect of tau on their motilitySemantic proximity Read

In-vivo fast non-linear microscopy reveals impairment of fast axonal transport induced by molecular motor imbalances in the brain of zebrafish larvaeSemantic proximity Read