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Article

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.

The American journal of pathology - 1 Feb 2013

Cherra Salvatore J, Steer Erin, Gusdon Aaron M, Kiselyov Kirill, Chu Charleen T

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial and sporadic cases of Parkinson disease. Mutant LRRK2 causes in vitro and in vivo neurite shortening, mediated in part by autophagy, and a parkinsonian phenotype in transgenic mice; however, the underlying mechanisms remain unclear. Because mitochondrial content/function is essential for dendritic morphogenesis and...

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Source

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Identifiers

PMID: 23231918
DOI: 10.1016/j.ajpath.2012.10.027
PMCID: PMC3562730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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