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Article

Cellular effects of LRRK2 mutations.

Biochemical Society transactions - 1 Oct 2012

Cookson Mark R

Abstract excerpt

Mutations in LRRK2 (leucine-rich repeat kinase 2) are a relatively common cause of inherited PD (Parkinson's disease), but the mechanism(s) by which mutations lead to disease are poorly understood. In the present paper, I discuss what is known about LRRK2 in cellular models, focusing specifically on assays that have been used to tease apart the effects of LRRK2 mutations on cellular phenotypes. LRRK2 expression...

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Identifiers

PMID: 22988867
DOI: 10.1042/BST20120165
PMCID: PMC4662252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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