Article
Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.
PloS one - 1 Jan 2013
Freeman David, Cedillos Rudy, Choyke Samantha, Lukic Zana, McGuire Kathleen, Marvin Shauna, Burrage Andrew M, Sudholt Stacey, Rana Ajay, O'Connor Christopher, Wiethoff Christopher M, Campbell Edward M
Abstract excerpt
α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread are poorly characterized. Recent studies of viruses and bacteria, which achieve their cytoplasmic entry by rupturing...
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