Article

Constitutive Endolysosomal Perforation in Neurons allows Induction of α-Synuclein Aggregation by Internalized Pre-Formed Fibrils

2024-01-01

Abstract excerpt

<h4>ABSTRACT</h4> The endocytic pathway is both an essential route of molecular uptake in cells and a potential entry point for pathology-inducing cargo. The cell-to-cell spread of cytotoxic aggregates, such as those of α-synuclein (α-syn) in Parkinson’s Disease (PD), exemplifies this duality. Here we used a human iPSC-derived induced neuronal model (iNs) prone to death mediated by aggregation in late endosomes a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2fb0442-59cb-5661-b6a6-7bab8f74f2df
DOI: 10.1101/2023.12.30.573738

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Constitutive Endolysosomal Perforation in Neurons allows Induction of α-Synuclein Aggregation by Internalized Pre-Formed FibrilsDOI 10.1101/2023.12.30.573738Read

α‐Synuclein fibrils explore actin‐mediated macropinocytosis for cellular entry into model neuroblastoma neuronsSemantic proximity Read

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Semantic proximity Read

Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s diseaseSemantic proximity Read

Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo EvidenceSemantic proximity Read

α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradationSemantic proximity Read

Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease.Semantic proximity Read

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.Semantic proximity Read

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusionsSemantic proximity Read

The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathiesSemantic proximity Read

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a <i>SNCA</i> TriplicationSemantic proximity Read

Parkinson’s Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein ClearanceSemantic proximity Read

LRRK2-I1371V Disrupts Astrocyte Membrane Homeostasis and Paradoxically Enhances α-Synuclein Toxicity Despite Impaired ClearanceSemantic proximity Read