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Article

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.

The Journal of biological chemistry - 11 Aug 2017

Karpowicz Richard J, Haney Conor M, Mihaila Tiberiu S, Sandler Raizel M, Petersson E James, Lee Virginia M-Y

Abstract excerpt

Direct cell-to-cell transmission of proteopathic α-synuclein (α-syn) aggregates is thought to underlie the progression of neurodegenerative synucleinopathies. However, the specific intracellular processes governing this transmission remain unclear because currently available model systems are limited. For example, in cell culture models of α-syn-seeded aggregation, it is difficult to discern intracellular from...

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PMID: 28611062
DOI: 10.1074/jbc.M117.780296
PMCID: PMC5555207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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