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Article

Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease.

Nature cell biology - 1 Mar 2026

Jacquemyn Julie, Marriott Brian, Chang Jinlan, Iftikhar Ehlam, Chik Kennedi, Lee Nathanael Y J, Rubio Atonal Luis F, Green Ceili, Wong Jeremy, Acevedo-Morantes Claudia, Chen Carol X-Q, Nicouleau Michael, You Zhipeng, Deneault Eric, Abdian Narges, Durcan Thomas M, Jackson Jesse, Ioannou Maria S

Abstract excerpt

The intercellular transmission of α-synuclein contributes to Parkinson's disease pathology. Yet, the mechanisms of α-synuclein spread are not fully understood. Here we used live-cell microscopy to examine the impact of Parkinson's disease associated lipid alterations on α-synuclein release. We discovered that increased glucosylceramides as a consequence of reduced β-glucocerebrosidase activity induce ectosome...

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PMID: 41680444
DOI: 10.1038/s41556-026-01871-6

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GBA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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