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Article

Probing determinants of cyclopiazonic acid sensitivity of bacterial Ca2+-ATPases.

The FEBS journal - 1 Nov 2013

Kotšubei Aljona, Gorgel Manuela, Morth Jens P, Nissen Poul, Andersen Jacob L

Abstract excerpt

Cyclopiazonic acid (CPA) is a specific and potent inhibitor of the sarcoplasmic reticulum Ca(2+)-ATPase 1a (SERCA1a). Despite high sequence similarity to SERCA1a, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) is not inhibited by CPA. To test whether a CPA binding site could be created while maintaining the functionality of the ATPase we targeted four amino acid positions in LMCA1 for mutational studies based on...

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PMID: 23621633
DOI: 10.1111/febs.12310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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