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Article

Overall mutational scanning unveils the essential active residues for the mechanistic action of MCR-1.

Microbiological research - 1 Feb 2025

Cheng Qipeng, Cheung Yanchu, Xu Chen, Chan Edward Wai Chi, Chan Kin Fai, Chen Sheng

Abstract excerpt

Polymyxins, including colistin and polymyxin B, serve as crucial last-resort antibiotics for managing infections caused by carbapenem-resistant Enterobacterales (CRE). However, the rapid spread of the mobilized colistin resistance gene (mcr-1) challenged the efficacy of treatment by polymyxins. The mcr-1 gene encoded a transmembrane phosphoethanolamine (PEA) transferase enzyme, MCR-1. MCR-1 could catalyze the...

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PMID: 39608179
DOI: 10.1016/j.micres.2024.127982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Overall mutational scanning unveils the essential active residues for the mechanistic action of MCR-1.PMID 39608179Read ↗

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