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Article

Structural basis of mycobacterial inhibition by cyclomarin A.

The Journal of biological chemistry - 25 Oct 2013

Vasudevan Dileep, Rao Srinivasa P S, Noble Christian G

Abstract excerpt

Cyclomarin A (CymA) was identified as a mycobactericidal compound targeting ClpC1. However, the target was identified based on pulldown experiments and in vitro binding data, without direct functional evidence in mycobacteria. Here we show that CymA specifically binds to the N-terminal domain of...

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Identifiers

PMID: 24022489
DOI: 10.1074/jbc.M113.493767
PMCID: PMC3829403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24022489-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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