Article
A cloned prokaryotic Cd2+ P-type ATPase increases yeast sensitivity to Cd2+.
Biochemical and biophysical research communications - 19 Nov 2004
Wu Chen-Chou, Bal Nathalie, Perard Julien, Lowe Jennifer, Boscheron Cécile, Mintz Elisabeth, Catty Patrice
Abstract excerpt
CadA, the P1-type ATPase involved in Listeria monocytogenes resistance to Cd(2+), was expressed in Saccharomyces cerevisiae and did just the opposite to what was expected, as it strikingly decreased the Cd(2+) tolerance of these cells. Yeast cells expressing the non-functional mutant Asp(398)Ala could grow on selective medium containing up to 100 microM Cd(2+), whereas those expressing the functional protein...
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