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Article

Single-molecule FRET studies of RNA folding: a Diels-Alderase ribozyme with photolabile nucleotide modifications.

The journal of physical chemistry. B - 24 Oct 2013

Kobitski Andrei Yu, Schäfer Stefan, Nierth Alexander, Singer Marco, Jäschke Andres, Nienhaus G Ulrich

Abstract excerpt

Enzymology at the single-molecule level by using fluorescence resonance energy transfer (smFRET) offers unprecedented insight into mechanistic aspects of catalytic reactions. Implementing spatiotemporal control of the reaction by using an external trigger is highly valuable in these challenging experiments. Here, we have incorporated a light-cleavable caging moiety into specific nucleotides of the Diels-Alderase...

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PMID: 23621553
DOI: 10.1021/jp402005m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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