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Article

Altering molecular recognition of RNA aptamers by allosteric selection.

Journal of molecular biology - 12 May 2000

Soukup G A, Emilsson G A, Breaker R R

Abstract excerpt

In a continuing effort to explore structural and functional dynamics in RNA catalysis, we have created a series of allosteric hammerhead ribozymes that are activated by theophylline. Representative ribozymes exhibit greater than 3000-fold activation upon effector-binding and cleave with maximum rate constants that are equivalent to the unmodified hammerhead ribozyme. In addition, we have evolved a variant...

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Source

Identifiers

PMID: 10788325
DOI: 10.1006/jmbi.2000.3704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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