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Article

Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy.

Nucleic acids research - 19 May 2017

Warhaut Sven, Mertinkus Klara Rebecca, Höllthaler Philipp, Fürtig Boris, Heilemann Mike, Hengesbach Martin, Schwalbe Harald

Abstract excerpt

The full-length translation-regulating add adenine riboswitch (Asw) from Vibrio vulnificus has a more complex conformational space than its isolated aptamer domain. In addition to the predicted apo (apoA) and holo conformation that feature the conserved three-way junctional purine riboswitch aptamer, it adopts a second apo (apoB) conformation with a fundamentally different secondary structure. Here, we...

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Identifiers

PMID: 28204648
DOI: 10.1093/nar/gkx110
PMCID: PMC5605240

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Source receipt: pubmed, retrieved 7 Sept 2026.

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