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Article

Differential regulation of protein subdomain activity with caged bivalent ligands.

Chembiochem : a European journal of chemical biology - 2 Mar 2009

Mayer Günter, Müller Jens, Mack Timo, Freitag Daniel F, Höver Thomas, Pötzsch Bernd, Heckel Alexander

Abstract excerpt

Subtle change: Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile "caging groups" to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain...

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Identifiers

PMID: 19189364
DOI: 10.1002/cbic.200800814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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