Article
Tuning a riboswitch response through structural extension of a pseudoknot.
Proceedings of the National Academy of Sciences of the United States of America - 27 Aug 2013
Soulière Marie F, Altman Roger B, Schwarz Veronika, Haller Andrea, Blanchard Scott C, Micura Ronald
Abstract excerpt
Structural and dynamic features of RNA folding landscapes represent critical aspects of RNA function in the cell and are particularly central to riboswitch-mediated control of gene expression. Here, using single-molecule fluorescence energy transfer imaging, we explore the folding dynamics of the preQ1 class II riboswitch, an upstream mRNA element that regulates downstream encoded modification enzymes of...
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