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Article

A structural intermediate pre-organizes the add adenine riboswitch for ligand recognition.

Nucleic acids research - 4 Jun 2021

St-Pierre Patrick, Shaw Euan, Jacques Samuel, Dalgarno Paul A, Perez-Gonzalez Cibran, Picard-Jean Frédéric, Penedo J Carlos, Lafontaine Daniel A

Abstract excerpt

Riboswitches are RNA sequences that regulate gene expression by undergoing structural changes upon the specific binding of cellular metabolites. Crystal structures of purine-sensing riboswitches have revealed an intricate network of interactions surrounding the ligand in the bound complex. The mechanistic details about how the aptamer folding pathway is involved in the formation of the metabolite binding site...

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Identifiers

PMID: 33963862
DOI: 10.1093/nar/gkab307
PMCID: PMC8191784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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