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Article

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease.

Cold Spring Harbor perspectives in medicine - 1 Mar 2012

Holtzman David M, Herz Joachim, Bu Guojun

Abstract excerpt

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease (AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system (CNS), apoE is produced by glial cells, is present in high-density-like lipoproteins, interacts with several receptors that are members of the low-density lipoprotein receptor (LDLR) family, and is a protein that binds to the...

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Source

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Identifiers

PMID: 22393530
DOI: 10.1101/cshperspect.a006312
PMCID: PMC3282491

Genes

LDLR
APOE
LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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