Article
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
Science translational medicine - 29 Jun 2011
Castellano Joseph M, Kim Jungsu, Stewart Floy R, Jiang Hong, DeMattos Ronald B, Patterson Bruce W, Fagan Anne M, Morris John C, Mawuenyega Kwasi G, Cruchaga Carlos, Goate Alison M, Bales Kelly R, Paul Steven M, Bateman Randall J, Holtzman David M
Abstract excerpt
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the APOE ε2 allele appears to decrease AD risk. Most rare, early-onset forms of familial AD are caused by autosomal...
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