Article
Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.
Gene - 15 Jul 2013
Iyer Sandhya N, Ankala Arunkanth, Singhal Rekha S, Hegde Madhuri R
Abstract excerpt
Cytidine deaminase (CDA) is the major enzyme involved in metabolism of gemcitabine, a pyrimidine analog widely used for chemotherapy of solid tumors. While only low amounts of administered gemcitabine undergo intracellular phosphorylation into active forms and involve in antineoplastic activities, majority of it is rapidly inactivated by CDA and excreted to avoid drug toxicity. Knowledge of the genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.