Article
PCR-based methods for CDA K27Q and A70T genotyping: genotypes and alleles distribution in a central Italy population.
Molecular biology reports - 1 Oct 2010
Carpi Francesco M, Vincenzetti Silvia, Micozzi Daniela, Vita Alberto, Napolioni Valerio
Abstract excerpt
Cytidine deaminase (CDA) is a pyrimidine salvage pathway enzyme that catalyzes the hydrolytic deamination of cytidine and deoxycytidine to their corresponding uracil nucleosides. CDA also catalyzes the inactivation of some chemotherapeutic nucleoside analogues such as cytosine arabinoside and gemcitabine. CDA 79A > C (K27Q, rs2072671) and 208G > A (A70T, rs60369023) were found to be associated either with...
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