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Article

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs.

Expert opinion on drug metabolism & toxicology - 1 May 2015

Serdjebi Cindy, Milano Gérard, Ciccolini Joseph

Abstract excerpt

INTRODUCTION: Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in the field of treating cancers, both in adults and in children. All these drugs act as antimetabolite compounds, that is, they interfere with the ability of cancer cells to synthesize the nucleosides or the nucleotides necessary for proliferation and progression. As with most cytotoxics, maintaining patients in their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25495470
DOI: 10.1517/17425255.2015.985648

Genes

CDA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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