Article
Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK).
Drug metabolism and pharmacokinetics - 1 Jan 2008
Kim Su-Ryang, Saito Yoshiro, Maekawa Keiko, Sugiyama Emiko, Kaniwa Nahoko, Ueno Hideki, Okusaka Takuji, Ikeda Masafumi, Morizane Chigusa, Yamamoto Noboru, Yoshida Teruhiko, Kamatani Naoyuki, Furuse Junji, Ishii Hiroshi, Saijo Nagahiro, Ozawa Shogo, Sawada Jun-Ichi
Abstract excerpt
Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the activation of nucleoside anticancer drugs, such as gemcitabine and cytarabine (Ara-C), to their active metabolites. In this study, the 5'-flanking region, 7 exons and their flanking introns of DCK were comprehensively screened for genetic variations in 256 Japanese cancer patients administered gemcitabine. Twenty-nine genetic variations, including twenty...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.