Article
High incidence of severe neutropenia after gemcitabine-based chemotherapy in Chinese cancer patients with CDA 79A>C mutation.
Clinica chimica acta; international journal of clinical chemistry - 16 Aug 2012
Xu Jialin, Zhou Yuhong, Zhang Jing, Chen Yuancheng, Zhuang Rongyuan, Liu Tianshu, Cai Weimin
Abstract excerpt
Cytidine deaminase (CDA) is a crucial enzyme in gemcitabine inactivation. Mutations in CDA gene have been found to influence the activity of CDA enzyme, which might lead to altered pharmacokinetics profile and clinical outcome of gemcitabine. In this study, the screening for the presence of CDA 79A>C and CDA 208G>A was performed by allele-specific PCR and restriction fragment length polymorphism, respectively. No...
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