Article
Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene.
Drug metabolism and pharmacokinetics - 1 Jan 2009
Sugiyama Emiko, Lee Su-Jun, Lee Sang Seop, Kim Woo-Young, Kim Su-Ryang, Tohkin Masahiro, Hasegawa Ryuichi, Okuda Haruhiro, Kawamoto Manabu, Kamatani Naoyuki, Sawada Jun-Ichi, Kaniwa Nahoko, Saito Yoshiro, Shin Jae-Gook
Abstract excerpt
Cytidine deaminase, encoded by the CDA gene, catalyzes anti-cancer drugs gemcitabine and ara-C into their respective inactive metabolites. In CDA, two functionally significant non-synonymous polymorphisms, 79A>C (Lys27Gln) and 208G>A (Ala70Thr), have been found and their minor allele frequencies (MAFs) were reported in Japanese and Chinese patients and a relatively small numbers of healthy volunteers in...
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