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Article

Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 2007

Sugiyama Emiko, Kaniwa Nahoko, Kim Su-Ryang, Kikura-Hanajiri Ruri, Hasegawa Ryuichi, Maekawa Keiko, Saito Yoshiro, Ozawa Shogo, Sawada Jun-ichi, Kamatani Naoyuki, Furuse Junji, Ishii Hiroshi, Yoshida Teruhiko, Ueno Hideki, Okusaka Takuji, Saijo Nagahiro

Abstract excerpt

PURPOSE: Gemcitabine is rapidly metabolized to its inactive metabolite, 2',2'-difluorodeoxyuridine (dFdU), by cytidine deaminase (CDA). We previously reported that a patient with homozygous 208A alleles of CDA showed severe adverse reactions with an increase in gemcitabine plasma level. This study extended the investigation of the effects of CDA genetic polymorphisms on gemcitabine pharmacokinetics and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17194903
DOI: 10.1200/JCO.2006.06.7405

Genes

CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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