Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.

Therapeutic drug monitoring - 1 Feb 2010

Raynal Caroline, Ciccolini Joseph, Mercier Cédric, Boyer Jean-Christophe, Polge Anne, Lallemant Benjamin, Mouzat Kévin, Lumbroso Serge, Brouillet Jean-Paul, Evrard Alexandre

Abstract excerpt

Gemcitabine (2',2'-difluorodeoxycytidine) is a major antimetabolite cytotoxic drug with a wide spectrum of activity against solid tumors. Hepatic elimination of gemcitabine depends on a catabolic pathway through a deamination step driven by the enzyme cytidine deaminase (CDA). Severe hematologic toxicity to gemcitabine was reported in patients harboring genetic polymorphisms in CDA gene. High-resolution melting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxycytidine

Share to Gemcitabine

Share to Neoplasms

Share to Polymerase Chain Reaction

Share to Reproducibility of Results

Share to Transition Temperature

Source

Identifiers

PMID: 20010457
DOI: 10.1097/FTD.0b013e3181c77c1b

Genes

CDA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.PMID 20010457Read ↗

Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.Semantic proximity Read ↗

The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?Semantic proximity Read ↗

High-resolution melting analysis (HRMA): more than just sequence variant screening.Semantic proximity Read ↗

Direct assessment of cytochrome P450 2D6 genotypes by high-resolution melting analysis and DNA sequencing.Semantic proximity Read ↗

Comprehensive analysis of UGT1A1 polymorphisms through high-resolution melting analysis and DNA sequencing.Semantic proximity Read ↗

Rapid screening for targeted genetic variants via high-resolution melting curve analysis.Semantic proximity Read ↗

Evaluation of High-Resolution Melting Analysis as a Diagnostic Tool to Detect the BRAF V600E Mutation in Colorectal TumorsSemantic proximity Read ↗

Cytidine deaminase polymorphism predicts toxicity of gemcitabine-based chemotherapy.Semantic proximity Read ↗

High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815.Semantic proximity Read ↗

T85C polymorphisms of the dihydropyrimidine dehydrogenase gene detected in gastric cancer tissues by high-resolution melting curve analysis.Semantic proximity Read ↗

Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation.Semantic proximity Read ↗

Enhanced primer selection and synthetic amplicon templates optimize high-resolution melting analysis of single-nucleotide polymorphisms in a large population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.