Article
Human cytidine deaminase: a biochemical characterization of its naturally occurring variants.
International journal of biological macromolecules - 1 Feb 2014
Micozzi Daniela, Carpi Francesco Martino, Pucciarelli Stefania, Polzonetti Valeria, Polidori Paolo, Vilar Santiago, Williams Brian, Costanzi Stefano, Vincenzetti Silvia
Abstract excerpt
Human cytidine deaminase is an enzyme of the pyrimidine salvage pathways that metabolizes several cytosine nucleoside analogs used as prodrugs in chemotherapy. We carried out a characterization of the cytidine deaminase 79A>C and 208G>A Single Nucleotide Polymorphisms, in order to highlight their functional role and provide data that could help fine-tune the chemotherapic use of cytosine nucleosides in patients...
Topics
- Antineoplastic Agents
- Catalysis
- Cytarabine
- Cytidine Deaminase
- Humans
- Kinetics
- Leukemia
- Mutagenesis, Site-Directed
- Polymorphism, Single Nucleotide