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Article

Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples.

Nucleosides, nucleotides & nucleic acids - 1 Jun 2008

Giovannetti E, Laan A C, Vasile E, Tibaldi C, Nannizzi S, Ricciardi S, Falcone A, Danesi R, Peters G J

Abstract excerpt

Cytidine deaminase (CDA) is the major enzyme of gemcitabine inactivation. The aim of this study was to determine whether the CDA Lys27Gln polymorphism influenced gemcitabine deamination in blood samples from 90 lung cancer patients. The polymorphism was studied with Taqman probes-based assay; CDA activity was evaluated by HPLC in cytoplasmic extracts from red blood cells. Mean enzymatic activity was significantly...

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Source

Identifiers

PMID: 18600531
DOI: 10.1080/15257770802145447

Genes

CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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