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Article

Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.

European journal of clinical pharmacology - 1 Aug 2006

Joerger M, Bosch T M, Doodeman V D, Beijnen J H, Smits P H M, Schellens J H M

Abstract excerpt

INTRODUCTION: Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates. This study was performed to assess the occurrence and frequency of DCK polymorphisms in a predominantly Caucasian population and to choose candidate polymorphisms for subsequent...

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Identifiers

PMID: 16799820
DOI: 10.1007/s00228-006-0162-7

Genes

DCK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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