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Article

Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2006

Gilbert Judith A, Salavaggione Oreste E, Ji Yuan, Pelleymounter Linda L, Eckloff Bruce W, Wieben Eric D, Ames Matthew M, Weinshilboum Richard M

Abstract excerpt

PURPOSE: Gemcitabine is a nucleoside analogue with activity against solid tumors. Gemcitabine metabolic inactivation is catalyzed by cytidine deaminase (CDA) or, after phosphorylation, by deoxycytidylate deaminase (DCTD). We set out to study the pharmacogenomics of CDA and DCTD. EXPERIMENTAL DESIGN: The genes encoding CDA and DCTD were resequenced using DNA from 60 African American and 60 Caucasian American...

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Source

Identifiers

PMID: 16551864
DOI: 10.1158/1078-0432.CCR-05-1969

Genes

CDA
DCTD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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