IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults.

doi:10.1016/j.neurobiolaging.2013.03.010

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Article

IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults.

Neurobiology of aging - 1 Sept 2013

McFall G Peggy, Wiebe Sandra A, Vergote David, Westaway David, Jhamandas Jack, Dixon Roger A

Abstract excerpt

We tested independent and interactive contributions of a recently noted and promising insulin degrading enzyme polymorphism (IDE; rs6583817) and type 2 diabetes (T2D) to executive function performance, concurrently and longitudinally. Regarding normal neurocognitive decline and Alzheimer's disease, T2D is a known risk factor and this IDE variant might contribute risk or risk reduction via the minor (A) or major...

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Identifiers

PMID: 23597493
DOI: 10.1016/j.neurobiolaging.2013.03.010
PMCID: PMC3679261

Genes

Variants

rs6583817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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