IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.

doi:10.1037/a0034656

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Article

IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.

Psychology and aging - 1 Jun 2014

McFall G Peggy, Wiebe Sandra A, Vergote David, Jhamandas Jack, Westaway David, Dixon Roger A

Abstract excerpt

OBJECTIVE: We report a gene × environment (health) study focusing on concurrent performance and longitudinal change in a latent-variable executive function (EF) phenotype. Specifically, we tested the independent and interactive effects of a recently identified insulin degrading enzyme genetic polymorphism (IDE rs6583817) and pulse pressure (PP; one prominent aging-related vascular health indicator) across up to 9...

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PMID: 24660790
DOI: 10.1037/a0034656
PMCID: PMC4069225

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