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Incidence and synergistic Association of Type 2 diabetes and apolipoprotein E epsilon 4 with dementia risk in the Kunshan aging research with E-health cohort study.

Preventive medicine - 1 Jan 2026

Dong Wanqing, Bai Jie, Wu Benrui, Zhou Kaixin, Jiang Hongwei

Abstract excerpt

OBJECTIVE: To investigate the independent and combined associations of type 2 diabetes (T2D) and APOE genotype on dementia risk. METHODS: We analyzed 104,911 participants aged ≥50 years from the Kunshan Aging Research with E-Health cohort (2018-2024). Incident dementia was identified using electronic medical records. Cox proportional hazards models and additive interaction analyses assessed associations and...

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PMID: 41202930
DOI: 10.1016/j.ypmed.2025.108439

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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